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Preoperative brachytherapy for early-stage cervical cancer: Systematic review and meta-analysis. Gynecol Oncol. 2022 Nov

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Viveros-Carreño D. 29/11/2022

Objective
To assess the rate of pathological response rate, and the oncological outcomes of preoperative brachytherapy (PBT) in early-stage cervical cancer.                                

Conclusion
Preoperative brachytherapy in patients with early-stage cervical cancer could improve pathologic and oncologic outcomes, but it should be assessed in high-quality randomized controlled trials before its implementation in clinical practice.

Investigación y educación

Prenatal cytogenetic diagnosis: results obtained in the specialized laboratory of Clínica Universitaria Colombia from 2013 to 2019. J Matern Fetal Neonatal Med.

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López Rivera JJ, Zapata Arizabaleta M, Carrillo YD, Gualdron López O.  01/09/2021

Objective
Prenatal cytogenetic evaluation is a key tool for identifying alterations in pregnant women with high risk for fetal chromosomal abnormalities (CA). In Colombia, there are not large-scale reports about the prevalence and pattern of CA in prenatal cytogenetic analysis.

Conclusion
In Colombia, the invasive prenatal cytogenetic analysis continues being an important diagnostic tool available for pregnant women with high risk for fetal CA.

Investigación y educación

Incidence of lymph node metastasis in early-stage low-grade serous ovarian cancer: a systematic review. Int J Gynecol Cancer.

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Viveros-Carreño D. 13/07/2022

Objective The objective of this systematic review was to assess the incidence of lymph node metastasis in patients with clinically presumed early-stage low-grade serous ovarian cancer that underwent primary surgical treatment.

Conclusion In patients with early-stage low-grade serous ovarian cancer, lymph node assessment should be discussed when counseling for primary surgical staging.

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Investigación y educación

Soluble concentrations of the terminal complement complex C5b-9 correlate with end-organ injury in preeclampsia.

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Valencia CM, Vargas-Rodríguez J, Bernal Y. 06/07/2022

Abstract
Objective
We sought to determine if soluble levels of C5b-9, the terminal complement complex, correlate with end-organ injury in preeclampsia.

Conclusion
We identified a pattern of increased urine and low plasma C5b-9 levels in patients with preeclampsia and end-organ injury. Soluble C5b-9 levels may be used to identify complement-mediated end-organ injury in preeclampsia.

Investigación y educación

Real-World Use of Generic Meropenem: Results of an Observational Study. Antibiotics (Basel).

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Garnica-Velandia S, Aristizábal-Ruiz LA, Alvarez-Moreno CA. 11/1/2021

Abstract
Background: To determine the therapeutic effect and tolerability of meropenem in routine clinical practice, in terms of clinical and microbiological response. Methods: A real-world, observational, descriptive, longitudinal study with daily monitoring of clinical history records was conducted on all patients who were medically prescribed meropenem during a period between October 2015 and March 2016 at a university hospital in Bucaramanga (Colombia). 

Investigación y educación